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A new study in mice may help explain some of the rare but strange adverse effects in people taking the sleep drug Ambien, including sleep walking, midnight binges and even driving while not fully awake. Ambien, made by Sanofi-Aventis, can shut down powerful brain circuits responsible for not allowing brain activity under certain circumstances, leaving other brain circuits unchecked, researchers at Georgetown University Medical Center in Washington said. You are kind of releasing the brakes, according to Molly Huntsman of Georgetown, who worked on the study that appears in the Proceedings of the National Academy of Sciences.
This may stimulate brain circuits that would normally be silenced and in a way, Ambien is awakening other circuits because the brakes are not in place," according to Huntsman.
To study the effects of the medication, known generically as zolpidem, Huntsman and colleagues conducted a series of experiments in mice. The team wanted to see how mice on the medication would react when the researchers trimmed their whiskers, which rodents use as their primary sensory system -- much like humans rely on vision to take in information about the world.
The team found that mice that were deprived of this sensory data had changes in their brain that affected the way they responded to the drug Ambien.
"It's a population of neurons that is usually in place to stop activity. We find what this drug does is inhibit their function to inhibit," Huntsman said in a telephone interview.
She said usually the drug has no effect on this group of neurons, but trimming the whiskers was enough to change brain receptors, making the mice respond differently to the drug.
"What's happening in the mouse brain is we are seeing the inhibitory neurons to become sensitive to Ambien, where they normally wouldn't be," she said.